I don’t believe this would help preserve any details… The TIFF should be already 16bit, which will be plenty of bit depth to retain details. Using a histogram adjustment in EpsonScan is just software stretching the existing scanned data.
I’m not sure the problem is “clipping” - if you were to use the clipping indicators in Lightroom (hit the “J” key while in the develop module), it wouldn’t be difficult to check and adjust to remove any actual clipping in the scene.
I think a lot of people expect film to have an “HDR” digital type like because of the high dynamic range of the film – but the HDR digital look is really has more to do with regional “tone mapping” which is not really what high dynamic range looks like… having an actually high dynamic range source will look more boring and low contrast.
See this thread for advise on how to process the film image by processing it multiple ways in NLP and using luminosity masks.