I have used a Nikon 5000ED for many thousands of scans, always with Vuescan (Professional version).
This scanner is also called the Nikon LS5000, and you can download the manual here: http://www.secrents.com/images/Nikon_Coolscan_5000_Instruction_Manual.pdf
There is a lot to learn about using Vuescan!
I always scan at 4000 dpi with IR (with no adjustments) and output the scan as a 64 bit RAW (tiff) file and store these images as backed-up archives. A typical 35mm scan is about 175MB, but storage is cheap. I do all my post processing with other software because Vuescan’s processing is very basic. I am now using NLP for negatives, previously I used ColorPerfect; I also use ColorPerfect for slides.
When I come to process a scan, I re-use Vuescan to read the archived RAW file as input, apply Light IR cleaning (which came to prefer to the Nikon version), and output the cleaned scan as a 48 bit raw DNG file, ready for NLP (the Vuescan instructions are a bit cryptic, but it’s all explained).
You’ll find that the slow step is the scanning, which starts with making sure the film is as clean as you can get it (IR cleaning is good, but it’s not a substitute for physical cleaning). If you have the automatic slide feeder, slides are easy - just stack them up and go away. Negatives are slower because you have to be present to keep loading the negative strips. It is essential to plan your naming and archiving system before you get serious about scanning a large number of images. Once you have the scans, Vuescan’s batch processing features make re-processing very quick and easy.