Hi!
In Vuescan in the input panel, are you scanning in “image” mode or “negative” mode? The ‘negative’ mode changes the gain of each of the color channels, and I believe the Coolscan 4000 can independently control this on the hardware side, so if you are consistently seeing strong orange casts, it’s possible something has gone wrong there.
If you send me a few raw images I can take a look.
Your histogram of the negative should look something like this…
…with the color channels separate and red on the furthest right area.
If you see that the the histogram is further to the right than the fourth quadrant on the right, it can be helpful to lower the exposure prior to conversion so that everything is to the left of fourth quadrant. Like this…
And then try the conversion.
I’m finding that Lightroom’s highlight compression can particularly screw things up with Vuescan DNGs.
-Nate