Adjusting analog gain in VueScan

I recently got a Coolscan 8000 and I’m using VueScan and NLP with it.

I have noticed in a few images after conversion the colors are better if I‘ve manipulated the RGB exposure and analog gain in VueScan to get a nice histogram.

I’ve read several places to just lock exposure for the roll and proceed so I’m not sure if these extra steps are worthwhile. Does anyone here have a similar workflow?

This post makes it seem like this is a bad idea.