@Maude, as far as see from my test setups, there is no simple answer to your questions. The number and size of negatives and how they are cut makes a difference. Let’s have a look at a few things to consider:
If I had to scan large negatives like 4x5, I’d opt for a vertical setup. Wet scanning could be an option for the very best few images or if dry scanning were not good enough.
If all I had were uncut 120 and smaller films, I’d go for a setup that allows to change negatives easily. Have a look at my vertical setup which makes serial scanning easy.
Short strips of film work well in a film strip holder that fits the format of the negatives. The digitaliza holder works well, but it does so only with shorter strips. Strips of four 645 negatives need repositioning, which is annoying.
A horizontal setup seems best for comfortable scanning because you can sit down and work with your head upright. No snaking around copy stand columns or tripod legs. Great for serial scanning.
A closed path between negative and camera looks like a very good idea because it eliminates stray light and creates a firm geometric coupling between negative and camera. Nothing moves around unless you want it to. A closed path allows for scanning during the day too. No need for a dim room or nightwork.
Tethering or no tethering? Tether if you can, it adds comfort.
Dust is omnipresent and a big pain.
All of the above are building blocks for your setup. See what you like best and what parts of the setup you have, can buy and what you can’t. This might tip the scale too. Your first setup does not have to be perfect. Start with what you have and see how far you get with it. You can always improve your setup later.
Does the above answer your questions? Probably not.